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LOS ANGELES http://www.grizzliesprostore.com/kids-lorenzen-wright-grizzlies-jersey/ , Jan. 30 (Xinhua) -- U.S. scientists have identified how a gene mutation affects T cell function to promote immune disorders and then tested a treatment based on the discovery--successfully fixing donated immune cells from a 16-year-old boy with an abnormally low level of white blood cells called lymphopenia.


Immune system disorders lead to abnormally low immune activity (deficiency) or overactivity (autoimmunity). Immune deficiency diseases decrease the body's ability to fight infection, while autoimmunity prompts the body to attack its own tissues. Both are common causes of illness, and malfunctioning T cells are linked to both.


The discovery, detailed in a paper published on Tuesday in Nature Communications, centers on mutation of the gene known as GTPase of immunity-associated protein 5 (Gimap5) http://www.grizzliesprostore.com/kids-jevon-carter-grizzlies-jersey/ , which is important to the healthy formation and function of CD4+ T cells, one of the immune system's super soldiers against infection and disease.


The protein associated with the Gimap5 gene, also Gimap5, is important because it regulates a protein that inactivates an enzyme called GSK3, researchers at the Cincinnati Children say in a news release.


""Our data suggest GSK3 inhibitors will improve T cell survival and function and may prevent or correct immune-related disorders in people with Gimap5 loss-of-function mutations http://www.grizzliesprostore.com/kids-jaren-jackson-jr-grizzlies-jersey/ ,"" Kasper Hoebe, PhD, Division of Immunobiology, was quoted as saying in a statement. ""Therapeutically targeting this pathway may be relevant for treating people with Gimap5 mutations linked to autoimmunity in Type 1 diabetes, systemic lupus erythematosus or asthma.""


According to the study http://www.grizzliesprostore.com/kids-jarell-martin-grizzlies-jersey/ , if GSK3 isn't inactivated it causes DNA damage in T cells that are expanding, causing the cells to not survive or function correctly.


The team, led by Hoebe, also identified a 16-year-old human patient with lymphopenia, who carried a rare http://www.grizzliesprostore.com/kids-garrett-temple-grizzlies-jersey/ , homozygous Gimap5 mutation that resulted in a complete lack of Gimap5 protein.


In mice and human blood cells, the researchers tested drugs that inhibit GSK3, improving immune system function in mice and restoring normal T cell function in the human cells.


GSK3 inhibitors already are used to treat other diseases like Alzheimer's, mood disorders and diabetes mellitus.


Researchers said additional research is needed before the data have clinical relevance for patients. New experiments are underway to translate the findings into the clinic, said Hoebe.



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WASHINGTON http://www.grizzliesprostore.com/kids-dillon-brooks-grizzlies-jersey/ , Jan. 29 (Xinhua) -- An American study shows that a disorder in sleep and wake cycle might be early signs for Alzheimer's disease.


The research at Washington University School of Medicine in St. Louis has indicated that the circadian rhythm disruption occurs much earlier in people whose memories are intact but whose brain scans show early, preclinical evidence of Alzheimer's.


The findings, published Monday in the journal of JAMA Neurology, could help doctors identify people at risk of Alzheimer's earlier than currently is possible, since Alzheimer's damage can take root in the brain 15 to 20 years before clinical symptoms appear.


""It wasn't that the people in the study were sleep-deprived http://www.grizzliesprostore.com/kids-chandler-parsons-grizzlies-jersey/ ,"" said first author Erik S. Musiek, an assistant professor of neurology. ""But their sleep tended to be fragmented. Sleeping for eight hours at night is very different from getting eight hours of sleep in one-hour increments during daytime naps.""


The researchers also conducted a separate study in mice, to be published Jan. 30 in The Journal of Experimental Medicine, showing that similar circadian disruptions accelerate the development of amyloid plaques in the brain, which are linked to Alzheimer's.


Previous studies at Washington University http://www.grizzliesprostore.com/kids-bryant-reeves-grizzlies-jersey/ , conducted in people and in animals, have found that levels of amyloid fluctuate in predictable ways during the day and night. Amyloid levels decrease during sleep, and several studies have shown that levels increase when sleep is disrupted or when people don't get enough deep sleep, according to research by senior author, Yo-El Ju.


""In this new study http://www.grizzliesprostore.com/kids-brice-johnson-grizzlies-jersey/ , we found that people with preclinical Alzheimer's disease had more fragmentation in their circadian activity patterns, with more periods of inactivity or sleep during the day and more periods of activity at night,"" said Ju, an assistant professor of neurology.


The study shows that subjects who experienced short spurts of activity and rest during the day and night were more likely to have evidence of amyloid buildup in their brains.


Both researchers said it's too early to answer the chicken-and-egg question of whether disrupted circadian rhythms put people at risk for Alzheimer's disease or whether Alzheimer's-related changes in the brain disrupt circadian rhythms.


""At the very least, these disruptions in circadian rhythms may serve as a biomarker for preclinical disease http://www.grizzliesprostore.com/kids-brandan-wright-grizzlies-jersey/ ,"" said Ju. ""We want to bring back these subjects in the future to learn more about whether their sleep and circadian rhythm problems lead to increased Alzheimer's risk or whether the Alzheimer's disease brain changes cause sleep and wake cycle and circadian problems.""

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